Thought you had put in your time, and knew all there was to know about depression and/or bipolar disorder? Think again; there are some truly unusual–and even bizarre–facts you might have missed.
DID YOU KNOW. . . .
That depression is experienced as anxiety 65 percent of the time?
That a study at the University of Texas found cognitive psychotherapy as effective as MAO inhibitors for major depressive disorder? (Jarrett 1999)
That there is significant disagreement in the medical community about the use of antidepressants for bipolar depression?
That the word ‘hippocampus‘ comes from the Greek, meaning ‘horse sea monster?’ Early scientists thought the hippocampus looked like a seahorse.
That it is estimated that nearly 50% of bipolar sufferers have comorbid addiction to drugs or alcohol?
That, statistically, bipolar sufferers have more heart problems than the rest of the population? They also have more headaches, particularly migraines.
That lithium makes concrete harden faster and can power small batteries?
That bipolar disorder is the sixth leading cause of disability in the world (WHO)?
That a 5 mg dose of Zyprexa causes an average weight gain of roughly 15 lbs after one year? (That’s according to a study by Charles B. Nemeroff, M.D., Ph.D. from Emory University School of Medicine.)
That, when bipolar is mis-diagnosed, women are more likely to be diagnosed with depression and men with schizophrenia?
That, according to the NIMH, the median age of onset for bipolar is 25 years of age?
That SSRIs like Prozac and Zoloft decrease the effects of LSD, while trycyclic antidepressants like Tofranil or Norpramine increase LSD effects? (Put that one in your pipe and smoke it.)
That only 1 in 4 bipolar sufferers receives an accurate diagnosis in less than 3 years?
That all of the following people were thought to now have or to have suffered from bipolar disorder in their lives: Agatha Christie, Drew Carey, Edgar Allen Poe, Isaac Newton, Jim Carey, Larry Flynt, and Winston Churchill?
That from 1993 to 2004, the diagnosis of bipolar disorder in children increased by 40 fold (Morena et al, 2007)?
That bananas have tryptophan, an amino acid that can convert to serotonin?
That Eli Lilly, makers of exponentially profitable Prozac and Zyprexa, had all of the following people on their payroll at one time or other: Former President George Herbert Walker Bush, Former CEO of Enron, Ken Lay, George W. Bush’s former director of Management and Budget, Mitch Daniels, and George W. Bush’s Homeland Security Advisory Council member, Sidney Taurel?
That a 2008 study by researchers at Brown University School of Medicine found that of 145 adults who said they had been diagnosed with bipolar disorder, 82 (57 percent) turned out not to have the condition, under further examination? [Booby prizes included major depression, borderline personality disorder, post-traumatic stress disorder (PTSD), generalized anxiety and social phobia.]
That the mood stabilizer Topomax is used off-label for sleep-related eating disorder (SRED)?
That one in ten Americans currently takes an antidepressant?
That the element lithium is toxic to humans?
That, according to NIMH, the atypical antipsychotic risperidone is a more effective treatment for children suffering manic episodes than the standard mood stabilizers? [Of course it still carries the threat of metabolic side effects.]
That blocking blue spectrum lights (fluorescent, incandescent and LED) is supposed to help reset circadian rhythms in the bipolar person?
That success rates of 80-90% were once the norm for lithium in treatment of acute mania while response rates of only 40-50% are now common (Frances et al., 1996)?
That some anti-seizure medications, often used in treating bipolar disorder (e.g. tegretol, depakote, trileptal, topomax) cause the liver to metabolize the estrogen in birth control pills more quickly, causing oral contraception to be less effective–or lose its efficacy completely?
That, according to Dr. Chris Lowry, a brain scientist at Bristol University in England, mycobacterium vaccae, a bacteria found in dirt, increases levels of seratonin in the brain, much as the SSRI’s do?
Maybe if we had only listened to our parents when they lost their patience and told us to go out and play in the dirt we would have been a generation that never needed Prozac.

Danny Haszard
February 1, 2012
Eli Lilly did make $65 billion on Zyprexa and they still expect to capture 20% of the US market as well as a billion year on Zyprexa XR.
Association Between Zyprexa and Hyperglycemia.
There is concern Zyprexa,like other atypical antipsychotic drugs, has the potential to cause metabolic disorders, particularly hyperglycemia (excess sugar) and diabetes. Atypical antipsychotics cause the body to metabolize fat instead of carbohydrates, leading to insulin resistance to the excess carbohydrates. At the same time they promote fat accumulation.I was a patient back in 1996-2000 who was a subject of Eli Lilly’s Zyprexa ‘viva’ Zyprexa’ off label sales promotion.I was given it as an ineffective costly treatment for PTSD It gave me diabetes as a side effect.–Daniel Haszard
Candida Abrahamson PhD
February 1, 2012
Thanks for your insightful comment, Daniel. I’m well aware of the dangers with the atypicals (of which metabolic syndrome, as you speak of, is a frightening eample, with zyprea leading the charge). I’m sorry you had to suffer from you attempts at healing–and hope you have found something less damaging to successfully fight your PTSD.
theartistryofthebipolarbrain
February 1, 2012
Very interesting and informative post!
Sadly, I did play in the dirt when I was a kid, including eating it. But maybe more bananas would help!
Candida Abrahamson PhD
February 1, 2012
Surely! And turkey, as I found out at http://www.angelfire.com/hi/TheSeer/seratonin.html. So we could have turkey hash topped by dirt-topped bananas and we’d be happy as clams.
Tegorsk Lico
February 4, 2013
No way to “like” this? I would if I could!
Kait
February 2, 2012
Very nice post!
Candida Abrahamson PhD
February 3, 2012
Thanks–and you, with your kind words and great blog name were a big draw. Yesterday the most links in my entire blog were to you! Enjoy.
lizziecracked
February 4, 2012
I am learning so much from reading and for once it is different information – it seems like you dig a little further than the majority acceptable – like if you were to Google it you would go to page 8348 instead of page 1 and I like that – I have to be really careful about reading about bipolar because it can be a trigger but I learn something new from you nearly every day since I found your blog. The one post about depression – the flying and …..got me in a funk but nothing like usual and i read my way out of it
Since you are on random facts about bipolar I wanted to know if it is true or if evidence supports that carb loading or a serious sweet tooth is a ..marker, byproduct, symptom…I don’t know what to call it of bipolar. ?
THankd for your very informative and helpful blog – I am inspired to think again about treatment and management with something other than solitary confinement
Candida Abrahamson PhD
February 4, 2012
I’m so so glad my words are helpful, and can serve as some sort of balm for your spirit. Your question is an excellent one. Off the top of my head I have two thoughts. First, “a serious sweet tooth” is often a side effect of several meds that are prescribed for bipolar disorder, particularly the atypicals, so keep that in mind. However, if that’s not what’s causing your sweet tooth, there is definitely research showing that craving sugar is a symptom of bipolar–so much so that it can be one of the clues when diagnosing the illness, just as you suspected. Take a look at http://www.everydayhealth.com/bipolar-disorder/sugar-and-bipolar-disorder.aspx for just one article on the topic. Keep believing, Candida
Candida Abrahamson PhD
February 5, 2012
And–actually, thank for the reminder on that one. I added it to the post. Be well, Candida
Jeraldine Kita
February 18, 2012
Really interesting articles. I enjoyed reading it.
Hayden Brianna Giddens
April 18, 2012
im a 13 year old girl that has bipolar and i would really like to know more about it and do medications always help
Candida Abrahamson PhD
April 18, 2012
Hi, Hayden, nice to hear from you. I’m assuming you received your diagnosis from a mental health professional, likely a child psychiatrist. It’s not appropriate for me to advise people under age 18. The best place to turn for information is your medical team and, if you’re the researching type, the public library. Beware of the internet; some very odd people are drawn to communicating in that anonymous way.
Candida
Yamaha power supply
October 24, 2012
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maria
January 9, 2013
those facts were soooo helpful i needed it for a project and it was amazing!!!!!